Gene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in the Rat Hippocampus during Morphine Withdrawal
نویسندگان
چکیده
Received: 23 December 2012 First Revision: 22 January 2013 Accepted: 17 February 2013 Shamseddin Ahmadi 1*, Shahin Amiri 1, Fatemeh Rafieenia1, Jalal Rostamzadeh1 1. Department of Biological Science and Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran.
منابع مشابه
Gene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in the Rat Hippocampus during Morphine Withdrawal
Introduction: Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence. Methods: In the present study, morphine tolerance was induced in male Wistar rats by 7 days repeated morphine injections once daily, and then gene expression profile of α-isoform of CaMKII (CaMKIIα) in the hipp...
متن کاملEffect of chronic morphine administration on Ca2+/Calmodulin-Dependent protein kinase IIα activity in rat locus coeruleus and its possible role in morphine dependency
Introduction: The aim of this study was to assess the effect of Ca2+/calmodulin-dependent kinase IIα (CaMKIIα) inhibitor (KN-93) injection into the locus coeruleus (LC) on the modulation of withdrawal signs. We also sought to study the effect of chronic morphine administration on CaMKIIα activity in the rat LC. Methods: The research was based on behavioral and molecular studies. In the behav...
متن کاملGene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in Rat's Hippocampus during Morphine Withdrawal
INTRODUCTION Calcium/calmodulin-dependent protein kinase II (CaMKII) which is highly expressed in the hippocampus is known to play a pivotal role in reward-related memories and morphine dependence. METHODS In the present study, repeated morphine injections once daily for 7 days was done to induce morphine tolerance in male Wistar rats, after which gene expression profile of α-isoform of CaMKI...
متن کاملActivation of calcium/calmodulin-dependent kinase II following bovine rotavirus enterotoxin NSP4 expression
Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...
متن کاملProteome Analysis of Rat Hippocampus Following Morphine-induced Amnesia and State-dependent Learning
Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...
متن کامل